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Search for "Buchwald–Hartwig reaction" in Full Text gives 6 result(s) in Beilstein Journal of Organic Chemistry.
Strategies in the synthesis of dibenzo[b,f]heteropines
Beilstein J. Org. Chem. 2023, 19, 700–718, doi:10.3762/bjoc.19.51
- categorised according to the major or final catalytic step employed to form the 7-membered heterocycle as several synthetic methods use multiple catalytic steps. 3.1 Buchwald–Hartwig amination, etherification and thioetherification The Buchwald–Hartwig reaction gives access to arylamines, -ethers and
Chemical syntheses and salient features of azulene-containing homo- and copolymers
Beilstein J. Org. Chem. 2021, 17, 2164–2185, doi:10.3762/bjoc.17.139
- effective electron delocalization along the C2 axis (C2v symmetry) passing through 2,6-positions of azulene [23][24][25]. The first chemical synthesis of such polyazulene called poly[2,6-aminoazulene] 31 was reported by Luh and co-workers [26] in 2017 and achieved by using the Buchwald–Hartwig reaction
- protocol (Scheme 7). The synthesis of the key building blocks 2-aminoazulene (24), 2-amino-6-bromoazulene (26), and its corresponding carbamate, tert-butyl N-(6-bromoazulen-2-yl)carbamate (27), used in their synthesis is presented in Scheme 7A. The carbamate 27 was subjected to a Buchwald–Hartwig reaction
Chan–Evans–Lam N1-(het)arylation and N1-alkеnylation of 4-fluoroalkylpyrimidin-2(1H)-ones
Beilstein J. Org. Chem. 2020, 16, 2304–2313, doi:10.3762/bjoc.16.191
- arylation of the nucleophilic nitrogen atom, known as the Ullmann [6][7] reaction, and its modification by Chan and Lam [8] are favored due to the several advantages they offer versus the Pd counterpart (i.e., the Buchwald–Hartwig reaction) such as the lower cost and lower toxicity of the metal as well as
Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles
Beilstein J. Org. Chem. 2019, 15, 2830–2839, doi:10.3762/bjoc.15.276
- , Québec, QC, G1V 4G2, Canada Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert Einstein Str. 29a, 18059 Rostock, Germany 10.3762/bjoc.15.276 Abstract A two-step palladium-catalyzed procedure based on Suzuki–Miyaura cross coupling, followed by a double Buchwald–Hartwig reaction, allows
- results were rationalized based on docking studies. Keywords: Buchwald–Hartwig reaction; cyclization; N-heterocycles; palladium; Suzuki–Miyaura reaction; Introduction Furoindoles and their derivatives have received a lot of attention based on their versatile pharmaceutical activities. Furoindols were
- diindolofurans by regioselective Suzuki–Miyaura couplings of tetrabromofuran and subsequent cyclization by tetrafold Buchwald–Hartwig reaction [31]. We also studied the synthesis of benzo[4,5]furo[3,2-b]indoles by a similar concept. However, while performing our studies, Truong et al. reported the synthesis of
Methyl isocyanide as a convertible functional group for the synthesis of spirocyclic oxindole γ-lactams via post-Ugi-4CR/transamidation/cyclization in a one-pot, three-step sequence
Beilstein J. Org. Chem. 2018, 14, 875–883, doi:10.3762/bjoc.14.74
- '-pyrrolidine]-2,5'-diones. Zhu et al. [38] reported 3-substituted-2-indolinones via a microwave-assisted post-Ugi-4CR/Buchwald–Hartwig reaction and another similar approach was illustrated by Van der Eycken et al. [39] for spiro[indoline-3,2'-pyrrole]-2,5'(1'H)-diones. In previous efforts to study 3
Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic
Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97
- treatment of bipolar disorder and schizophrenia [10]. The process involves four reaction steps, one inline extraction, and a filtration step. The reaction is shown in Scheme 1. Initially, a Buchwald–Hartwig reaction is carried out between aryl iodide and aminothiazole. Pd2dba3 was used as a catalyst and
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